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Updated: Feb 2, 2026
09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
10.1K
[Invasive aspergillosis in solid organ transplantation]
José Tiago Silva1, Julián Torre-Cisneros2, José María Aguado1
1Unidad de Enfermedades Infecciosas, Instituto de Investigación Hospital Universitario 12 de Octubre (i+12), Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, España.
Revista Iberoamericana De Micologia
|November 24, 2018
Summary
Solid organ transplant recipients face high risks of invasive fungal infections (IFI). Isavuconazole offers a safer treatment option, reducing drug interactions and side effects compared to older antifungals.
Area of Science:
- Medical Mycology
- Transplantation Medicine
- Pharmacology
Background:
- Solid organ transplant (SOT) recipients are highly susceptible to invasive fungal infections (IFI).
- Current treatments face challenges due to drug interactions with immunosuppressants and toxicity concerns (e.g., hepatotoxicity with voriconazole, nephrotoxicity with amphotericin B).
Observation:
- Isavuconazole, a newer triazole antifungal, demonstrates favorable pharmacokinetic properties, good tolerability, and a low adverse effect profile.
- Published data suggest isavuconazole has a reduced risk of interaction with tacrolimus and is less hepatotoxic than voriconazole in SOT patients.
Findings:
- Isavuconazole appears to mitigate treatment-related side effects in SOT patients with IFI.
- Patient and SOT type variability exists, necessitating individualized treatment approaches.
Implications:
- Isavuconazole presents a promising therapeutic option for managing IFI in SOT recipients.
- Further clinical trials are warranted to explore its efficacy in both treatment and prophylaxis of IFI in this vulnerable population.
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