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Erectile dysfunction in compensated liver cirrhosis.

Sergio Maimone1, Francesca Saffioti2, Giovanni Oliva1

  • 1Division of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|November 24, 2018
PubMed
Summary

Erectile dysfunction (ED) affects over half of men with compensated cirrhosis, increasing with age. Older age and low hemoglobin are key predictors, not the liver condition itself.

Keywords:
Child Pugh ACompensated chronic liver diseaseErectile dysfunctionLiver cirrhosisSexual disturbance

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Area of Science:

  • Gastroenterology
  • Urology
  • Andrology

Background:

  • Limited data exists on erectile dysfunction (ED) in cirrhotic patients.
  • Compensated cirrhosis is common, affecting numerous male patients.
  • Understanding ED prevalence and contributing factors is crucial for patient care.

Purpose of the Study:

  • To determine the prevalence of erectile dysfunction (ED) in men with compensated cirrhosis.
  • To identify factors associated with the development of ED in this population.
  • To assess the impact of cirrhosis severity and comorbidities on ED.

Main Methods:

  • Prospective enrollment of 102 male patients with Child-Pugh Class A compensated cirrhosis.
  • Utilized validated questionnaires: IIEF-5 for ED, CES-D for depression, and ANDROTEST for hormonal assessment.
  • Collected data on age, comorbidities (diabetes, hypertension, cardiovascular disease), and serum hemoglobin levels.

Main Results:

  • Erectile dysfunction (ED) was prevalent in 55.9% of patients, with varying severity.
  • ED prevalence increased significantly with age (p=0.006).
  • Older age (p=0.040) and lower serum hemoglobin (p=0.027) were identified as independent predictors of ED.

Conclusions:

  • Compensated cirrhosis itself is not a significant risk factor for erectile dysfunction (ED).
  • The prevalence of ED in compensated cirrhosis is comparable to the general population.
  • Older age and low hemoglobin levels are key factors associated with ED in cirrhotic patients.