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Related Experiment Video

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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine.

E Ghione1, N Bergsland1, M G Dwyer1,2

  • 1From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center.

AJNR. American Journal of Neuroradiology
|November 24, 2018
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Summary
This summary is machine-generated.

Brain atrophy measurement in multiple sclerosis (MS) is feasible and linked to disability. Lateral ventricle volume changes are the most practical to assess, aiding in monitoring MS progression.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Imaging Analysis

Background:

  • Brain atrophy assessment is not routinely performed in clinical multiple sclerosis (MS) management.
  • Longitudinal monitoring of brain volume changes is crucial for understanding MS progression.

Purpose of the Study:

  • To assess the feasibility of measuring brain atrophy in routine clinical practice for multiple sclerosis (MS) patients.
  • To determine the association between brain atrophy and disability progression over a 5-year period in MS patients.

Main Methods:

  • Retrospective analysis of 1815 subjects (1514 MS, 137 CIS, 164 healthy controls).
  • Utilized 11,794 MRI brain scans (3T and 1.5T) with 3D T1WI and T2-FLAIR sequences.
  • Measured whole-brain volume changes (SIENA/SIENAX) and lateral ventricle volume changes (NeuroSTREAM).

Main Results:

  • Brain volume measures significantly differed between MS patients and healthy individuals.
  • Disability progression in MS was associated with annualized brain volume decrease and lateral ventricle volume increase.
  • Feasibility rates varied: percentage brain volume change (36.7% failure), normalized brain volume change (19.2% failure), and lateral ventricle volume change (3.3% failure).

Conclusions:

  • All assessed brain volume measures differentiated MS from healthy individuals and correlated with disability progression.
  • Lateral ventricle volume assessment demonstrated the highest feasibility for routine clinical use in monitoring MS.
  • Brain atrophy measurement, particularly of the lateral ventricles, can aid in tracking MS progression and disability.