Related Experiment Video
Updated: Jul 12, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Olfactory function and olfactory bulb volume in Wilson's disease
Nazan Degirmenci1, Bayram Veyseller2, Hasmet Hanagasi3
1Department of Otorhinolaryngology and Head and Neck Surgery, Bezmialem Vakif University, Istanbul, Turkey. nzndegirmenci@hotmail.com.
Purpose:
To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson's Disease (WD) patients.
Methods:
A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.
Results:
There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).
Conclusions:
WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.
More Related Videos
08:33Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Published on: December 4, 2014
07:13Experience-Dependent Remodeling of Juvenile Brain Olfactory Sensory Neuron Synaptic Connectivity in an Early-Life Critical Period
Published on: March 1, 2024
Related Concept Videos
Olfaction
The olfactory receptors are embedded in the cilia of the...
Lysosomal Hydrolases
Olfactory Receptors: Location and Structure
Physiology of Smell and Olfactory Pathway
The olfactory...