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A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
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TIRADS Interobserver Variability Among Indeterminate Thyroid Nodules: A Single-Institution Study.

Zeyad T Sahli1,2, Ashwyn K Sharma1, Joseph K Canner1

  • 1Endocrine Surgery, Department of Surgery, Baltimore, Maryland.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

The Thyroid Imaging Reporting and Data System (TIRADS) showed fair interobserver variability for suspicious thyroid nodules. Shape and margin features contributed most to disagreements, indicating a need for further research.

Keywords:
AfirmaTIRADSendocrine surgeryindeterminate nodulesinterobserver variabilitythyroid

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Area of Science:

  • Endocrinology
  • Radiology
  • Pathology

Background:

  • A significant portion of cytologically indeterminate and Afirma Gene Expression Classifier "suspicious" thyroid nodules are benign.
  • The American College of Radiology's 2017 Thyroid Imaging Reporting and Data System (TIRADS) provides standardized ultrasound-based classification for thyroid nodules to guide management.

Purpose of the Study:

  • To assess the interobserver variability of TIRADS classification specifically for cytologically indeterminate and Afirma suspicious thyroid nodules.

Main Methods:

  • Retrospective analysis of 127 thyroid fine-needle aspiration specimens with indeterminate diagnosis, Afirma suspicious results, and subsequent surgery.
  • Three blinded radiologists evaluated TIRADS classification.
  • Interobserver variability was quantified using intraclass correlation coefficients (ICCs).

Main Results:

  • Overall TIRADS score and category interobserver variability was fair (ICC=0.561 and 0.547, respectively).
  • Variability was fair for composition (ICC=0.552), echogenicity (ICC=0.533), and echogenic foci (ICC=0.549).
  • Shape (ICC=0.359) and margin (ICC=0.192) criteria demonstrated poor interobserver agreement.

Conclusions:

  • TIRADS classification exhibits fair interobserver variability in cytologically indeterminate and Afirma suspicious thyroid nodules.
  • Disagreements in classifying nodule shape and margin are primary drivers of variability.
  • Further prospective studies are warranted to validate TIRADS interobserver variability in this specific patient subgroup.