Long noncoding RNAs as biotargets in cisplatin-based drug resistance

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Cisplatin is a cornerstone chemotherapy drug for various cancers.
• Cancer chemoresistance, particularly to cisplatin, presents a significant clinical challenge.
• Chemoresistance involves complex, multifactorial cellular pathways.

Purpose of the Study:

• To review the current understanding of long noncoding RNAs (lncRNAs) in regulating cisplatin resistance.
• To highlight the role of lncRNAs as potential biomarkers and therapeutic targets in overcoming chemoresistance.

Main Methods:

• Literature review of studies investigating the link between lncRNAs and cisplatin resistance.
• Analysis of molecular mechanisms by which lncRNAs modulate cellular responses to cisplatin.

Main Results:

• Dysregulation of numerous lncRNAs is associated with drug resistance in cancers.
• Specific lncRNAs have been identified as critical regulators of cisplatin resistance.
• lncRNAs influence multiple cellular pathways involved in cisplatin sensitivity and resistance.

Conclusions:

• lncRNAs represent a promising area for understanding and potentially overcoming cisplatin resistance.
• Targeting specific lncRNAs may offer novel therapeutic avenues to enhance cisplatin efficacy in cancer treatment.