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Related Experiment Videos

Systemic absorption of topically applied ocular atropine.

K Lahdes1, T Kaila, R Huupponen

  • 1Department of Pharmacology, University of Turku, Finland.

Clinical Pharmacology and Therapeutics
|September 1, 1988
PubMed
Summary

Ocular atropine absorption is rapid, reaching peak plasma levels within 8 minutes. While it did not significantly impact blood pressure or heart rate, it showed a slight, insignificant reduction in salivary secretion.

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Area of Science:

  • Ophthalmology
  • Pharmacokinetics
  • Clinical Pharmacology

Background:

  • Atropine is commonly used in ophthalmology.
  • Understanding its systemic absorption and effects after ocular administration is crucial for patient safety.

Purpose of the Study:

  • To quantify atropine plasma levels after ocular application.
  • To monitor systemic effects including blood pressure, heart rate, and salivary secretion.

Main Methods:

  • Eight patients received 1% atropine eyedrops in one eye.
  • Plasma atropine levels were measured via radioreceptor assay for 90 minutes.
  • Blood pressure, heart rate, and salivary secretion were monitored.

Main Results:

  • Peak plasma atropine concentration (860 +/- 402 pg/ml) reached within 8 minutes.

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  • Ocular absorption rate comparable to intramuscular administration.
  • No significant changes in blood pressure or heart rate observed.
  • Salivary secretion showed a statistically insignificant reduction at 30 minutes.

    • Conclusions:

    • Ocular atropine demonstrates rapid systemic absorption.
    • Systemic side effects on cardiovascular parameters are minimal.
    • Further investigation may be needed for salivary effects.