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Updated: Feb 2, 2026
Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
Published on: January 16, 2020
Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer
Şükrü Tüzmen1,2, Galen Hostetter2,3, Aprill Watanabe2,4
1Department of Biological Sciences, Molecular Biology & Genetics Program, Faculty of Arts & Sciences, Eastern Mediterranean University (EMU), Famagusta, North Cyprus via Mersin 10, 99628, Turkey.
Aim:
To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.
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