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Updated: Feb 2, 2026

Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures without Metal Nanoparticles while Retaining Gas-phase Bioactivity
Published on: March 1, 2016
pH-Induced reorientation of cytochrome c on silica nanoparticles
Jens Meissner1, Yao Wu2, Jacques Jestin3
1Stranski Laboratory of Physical and Theoretical Chemistry, Technical University Berlin, 10623 Berlin, Germany. findenegg@chem.tu-berlin.de.
Abstract:
The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.
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