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KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A

Matteo Bassetti1, Novella Carannante2, Carlo Pallotto3

  • 1Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.

Journal of Global Antimicrobial Resistance
|November 24, 2018
PubMed
Abstract

Insights

Ceftazidime/avibactam (CAZ/AVI) therapy shows promise for decolonizing the gut of KPC-producing Klebsiella pneumoniae (KPC-Kp). This approach may prevent systemic infections in high-risk patients.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Gut colonization by KPC-producing Klebsiella pneumoniae (KPC-Kp) is a significant risk factor for invasive infections.
  • Effective decolonization strategies are crucial for preventing severe outcomes in high-risk individuals.

Purpose of the Study:

  • To evaluate the efficacy of ceftazidime/avibactam (CAZ/AVI)-based therapy for KPC-Kp gut decolonization.
  • To compare CAZ/AVI therapy with other antimicrobial regimens in patients with KPC-Kp infection.

Main Methods:

  • Retrospective, observational, multicenter study design.
  • Comparison of KPC-Kp gut decolonization rates between CAZ/AVI therapy (Group A) and other antimicrobial regimens (Group B).

Main Results:

  • High gut decolonization rate (91.7%) was achieved with CAZ/AVI-based therapy in 11 out of 12 patients.
  • No gut decolonization was observed in the 24 patients treated with other antimicrobial regimens (Group B).

Conclusions:

  • CAZ/AVI-based therapy demonstrates significant potential for KPC-Kp gut decolonization.
  • This therapeutic approach may be beneficial for high-risk patients requiring KPC-Kp decolonization.
Keywords:
Carbapenemase-producing Klebsiella pneumoniaeCeftazidimeCeftazidime/avibactamGut decolonisationKPC

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