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Cancer epigenetics and the potential of epigenetic drugs for treating solid tumors

Zhenghui Liu1, Yingxue Gao1, Xiong Li1

  • 1a Xiangya Hospital, Central South University , Changsha , Hunan , China.

Expert Review of Anticancer Therapy
|November 25, 2018
PubMed

Insights

Epigenetic drugs show promise for cancer treatment, but their effectiveness in solid tumors is limited. Future strategies involve next-generation inhibitors and combination therapies for improved outcomes.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacology

Background:

  • Epigenetic modifications, crucial in cancer development, are targeted by approved drugs for hematological malignancies.
  • Current epigenetic drugs show limited efficacy in solid tumors, with mechanisms often unclear.

Purpose of the Study:

  • To review current research on cancer epigenetics.
  • To discuss the potential and limitations of epigenetic drugs for solid tumors.
  • To analyze reasons for treatment failures and explore future development.

Main Methods:

  • Literature review of recent studies on cancer epigenetics.
  • Analysis of clinical trial data for epigenetic drug efficacy in solid tumors.
  • Discussion of emerging therapeutic strategies.

Main Results:

  • Epigenetic drugs have shown success in blood cancers but not solid tumors.
  • Understanding the mechanisms of action and resistance is critical for solid tumor treatment.
  • Combination therapies and novel drug development are key.

Conclusions:

  • Next-generation epigenetic inhibitors targeting novel regulators offer improved specificity.
  • Combining epigenetic drugs with chemotherapy, radiotherapy, targeted therapy, or immunotherapy holds promise for treating solid tumors.
Keywords:
Epigeneticscombination therapyepigenetic drugshematologic malignanciessolid tumors

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