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Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives
Henry M Kariithi1, Irene K Meki2,3, Daniela I Schneider4
1Biotechnology Research Institute, Kenya Agricultural & Livestock Research Organization, P.O Box 57811, 00200, Kaptagat Rd, Loresho, Nairobi, Kenya.
BMC Microbiology
|November 25, 2018
Summary
Controlling African trypanosomosis relies on managing tsetse flies, as vaccines are unavailable. Research enhanced the sterile insect technique (SIT) by studying tsetse-pathogen interactions to improve disease control.
Area of Science:
- Vector-borne diseases
- Neglected tropical diseases
- Entomology and Parasitology
Background:
- African trypanosomosis control hinges on tsetse fly vector management due to lack of vaccines and drugs.
- The sterile insect technique (SIT) is effective for area-wide tsetse fly eradication in isolated populations.
Discussion:
- A five-year (2013-2018) Coordinated Research Project (CRP) investigated tsetse-trypanosome interactions to enhance SIT effectiveness.
- The CRP focused on elucidating molecular interactions between tsetse, their symbionts, and the trypanosome pathogen.
Key Insights:
- Understanding tsetse-symbiome-pathogen molecular interactions is crucial for improving SIT and developing compatible interventions.
- Enhancing vector refractoriness to trypanosomes can improve SIT efficacy and expand its application in disease-endemic areas.
Outlook:
- The research provides science-based perspectives for mitigating or eradicating African trypanosomosis.
- Future strategies may involve integrating enhanced SIT with other interventions for comprehensive vector control.
Keywords:
GlossinaHytrosaviridaeMicrobiotaParatransgenesisTrypanosoma-refractoriness, sterile insect techniqueVector competenceMore Related Videos
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