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Updated: Feb 2, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
Low-Grade Glioma Radiotherapy Treatment and Trials
Tony J C Wang1, Minesh P Mehta2
1Department of Radiation Oncology, Columbia University Medical Center, 622 West 168th Street, BNH B-11, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.
Abstract:
Low-grade gliomas represent an important class of primary brain tumors. They account for approximately 20% of primary brain tumors and typically present in the fourth decade of life. Standard management gliomas involves observation, surgery, chemotherapy, and/or radiotherapy. Treatment decisions are based on many factors including prognostic molecular markers, potential benefits of increased progression-free survival, and potential long-term treatment complications. Recent studies have improved our understanding regarding therapeutic interventions. This review provides an overview of low-grade glioma and discusses the roles of radiation therapy. We discuss advances in techniques and recent and ongoing radiation therapy-related clinical trials for low-grade gliomas.
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