TRPM7 reflected in Cryo-EMirror
Related Experiment Video
Updated: Feb 2, 2026

Preparation of High-Temperature Sample Grids for Cryo-EM
Published on: July 26, 2021
Vladimir Chubanov1, Lorenz Mittermeier1, Thomas Gudermann2
1Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany.
Abstract:
TRPM7 is an atypical type of ion channel because its pore-forming moiety is covalently linked to a protein kinase domain. The channel-kinase TRPM7 controls a wide range of biological processes such as mineral homeostasis, immune responses, cell motility, proliferation and differentiation. Earlier this year, Duan J & co-workers [1] published three TRPM7 structures resolved by cryo-electron microscopy (cryo-EM). This study tremendously advances our mechanistic understanding of TRPM7 channel function and forms the basis for informed structure-function assessment of this extraordinary protein.
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