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Cognitive function assessment in elderly patients with overactive bladder treated with transdermal oxybutynin
C Müller-Arteaga1, J E Batista-Miranda2, C Zubiaur Libano3
1Complejo Hospitalario Universitario de Ourense, Ourense, España.
Actas Urologicas Espanolas
|November 25, 2018
Summary
Transdermal oxybutynin treatment for overactive bladder in older adults did not cause cognitive impairment. Patients experienced improved urinary urgency symptoms and maintained good treatment adherence.
Area of Science:
- Geriatrics
- Urology
- Pharmacology
Background:
- Older adults with overactive bladder (OAB) on antimuscarinic drugs are at increased risk for cognitive impairment.
- Transdermal oxybutynin offers an alternative OAB treatment, but its short-term cognitive effects in the elderly require evaluation.
Purpose of the Study:
- To assess short-term cognitive function changes in elderly OAB patients treated with transdermal oxybutynin.
- To evaluate the impact of transdermal oxybutynin on OAB symptoms and treatment adherence in older adults.
Main Methods:
- A retrospective, multicenter observational study involving 70 patients aged 65-80 with OAB.
- Cognitive function was assessed using the Memory Alteration Test and Clock-Drawing Test before and after one month of transdermal oxybutynin treatment.
- OAB symptom severity, patient-reported outcomes, and treatment adherence were also evaluated.
Main Results:
- No significant cognitive impairment was observed after one month of transdermal oxybutynin use (Memory Alteration Test: +1 point; Clock-Drawing Test: 0 points).
- Statistically significant improvements were noted in OAB storage symptoms (P<.001) and bother scores.
- 72.8% of patients reported symptom improvement, with 84.3% treatment adherence.
Conclusions:
- Transdermal oxybutynin treatment for OAB in elderly patients is not associated with short-term cognitive impairment.
- The treatment effectively improves OAB storage symptoms and demonstrates adequate patient adherence.
- Transdermal oxybutynin represents a safe and effective option for managing OAB in older adults.
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