Related Experiment Video
Updated: Feb 2, 2026
07:36
Isolation of Mouse Coronary Endothelial Cells
Published on: July 3, 2016
12.0K
Relationship between interleukin-17A and isolated coronary ectasia
Turgut Uygun1, Bülent Demir2, Veysel Tosun1
1Department of Cardiology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey.
Cytokine
|November 25, 2018
Summary
Serum interleukin (IL)-17A levels are significantly elevated in patients with coronary artery ectasia (CAE). This study found higher IL-17A in CAE patients compared to controls, suggesting a link between IL-17A and ectasia formation.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Background:
- Coronary artery ectasia (CAE) is a coronary artery disease characterized by abnormal dilation.
- The role of inflammation, particularly interleukin-17A (IL-17A), in CAE pathogenesis is not fully understood.
Purpose of the Study:
- To evaluate serum IL-17A levels in patients with CAE.
- To investigate the relationship between IL-17A and CAE.
- To determine if IL-17A levels correlate with the severity of coronary ectasia.
Main Methods:
- Serum IL-17A levels were measured using enzyme-linked immunosorbent assay (ELISA).
- Patients with CAE (n=41) and a control group with normal coronary arteries (n=45) were included.
- Echocardiographic assessments were performed.
Main Results:
- IL-17A levels were significantly higher in patients with isolated CAE compared to the control group (4.86 ± 3.24 ng/ml vs. 1.37 ± 1.56 ng/ml, p < 0.001).
- CAE patients exhibited increased levels of IL-17A, fibrinogen, and red blood cell distribution width (RDW) compared to controls.
- No correlation was found between IL-17A levels and the extent of CAE, although levels remained high in both groups.
Conclusions:
- Elevated serum IL-17A levels are associated with the presence of coronary artery ectasia.
- Increased IL-17A may play a role in the development of ectasia in CAE patients.
Related Concept Videos
02:12Relationship Formation
46.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
01:28Ending Relationships
189
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
189
01:27Relationship Growth
218
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
218
01:21Coronary Circulation
7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
01:30Social Relationships and Well-Being
313
The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
313
01:29Close Relationships and Culture
239
Culture shapes how people approach attraction, choose partners, and build long-term relationships. While some preferences in mate selection appear consistent across cultures, such as men valuing physical attractiveness and women emphasizing financial resources, cultural contexts influence how these preferences are expressed and prioritized. Marriage extends beyond romantic ideals in many societies and is deeply embedded in social, economic, and religious frameworks.The Role of Culture in Mate...
239