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Relationship between interleukin-17A and isolated coronary ectasia

Turgut Uygun1, Bülent Demir2, Veysel Tosun1

  • 1Department of Cardiology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey.

Cytokine
|November 25, 2018
PubMed

Insights

Serum interleukin (IL)-17A levels are significantly elevated in patients with coronary artery ectasia (CAE). This study found higher IL-17A in CAE patients compared to controls, suggesting a link between IL-17A and ectasia formation.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Coronary artery ectasia (CAE) is a coronary artery disease characterized by abnormal dilation.
  • The role of inflammation, particularly interleukin-17A (IL-17A), in CAE pathogenesis is not fully understood.

Purpose of the Study:

  • To evaluate serum IL-17A levels in patients with CAE.
  • To investigate the relationship between IL-17A and CAE.
  • To determine if IL-17A levels correlate with the severity of coronary ectasia.

Main Methods:

  • Serum IL-17A levels were measured using enzyme-linked immunosorbent assay (ELISA).
  • Patients with CAE (n=41) and a control group with normal coronary arteries (n=45) were included.
  • Echocardiographic assessments were performed.

Main Results:

  • IL-17A levels were significantly higher in patients with isolated CAE compared to the control group (4.86 ± 3.24 ng/ml vs. 1.37 ± 1.56 ng/ml, p < 0.001).
  • CAE patients exhibited increased levels of IL-17A, fibrinogen, and red blood cell distribution width (RDW) compared to controls.
  • No correlation was found between IL-17A levels and the extent of CAE, although levels remained high in both groups.

Conclusions:

  • Elevated serum IL-17A levels are associated with the presence of coronary artery ectasia.
  • Increased IL-17A may play a role in the development of ectasia in CAE patients.

Keywords:
AtherosclerosisCoronary artery ectasiaFibrinogenInterleukin-17ARed cell distribution width

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