Related Experiment Video
Updated: Feb 2, 2026

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
Published on: November 4, 2010
The Aalborg Bolt-Connected Drain (ABCD) study: a prospective comparison of tunnelled and bolt-connected external
Sofia Kamakh Asaad1, Carsten Reidies Bjarkam2
1Department of Neurosurgery, Institute of Clinical Medicine, Aalborg University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark. s.asaad@rn.dk.
Insights
Bolt-connected external ventricular drainage (BC-EVD) significantly reduces complications compared to traditional tunnelled EVD (T-EVD). BC-EVD should be the preferred method for EVD placement due to its lower complication rates.
Area of Science:
- Neurosurgery
- Medical Devices
- Patient Safety
Background:
- Acutely increased intracranial pressure (ICP) management often involves external ventricular drainage (EVD).
- Standard tunnelled EVD (T-EVD) carries a high complication rate.
- Bolt-connected EVD (BC-EVD) is a newer technique proposed to reduce complications.
Purpose of the Study:
- To prospectively compare complication rates between BC-EVD and T-EVD.
- To evaluate the efficacy of BC-EVD in reducing adverse events associated with EVD placement.
Main Methods:
- Prospective cohort study comparing BC-EVD and T-EVD over 12 months.
- Neurosurgical decision-making determined EVD type allocation.
- Complications including CSF leakage, infection, and hemorrhage were systematically recorded.
Main Results:
- Fewer complications were observed in the BC-EVD group (17.6%) compared to the T-EVD group (59.4%).
- The relative risk of complications with T-EVD was 3.4 times higher than with BC-EVD (p=0.007).
Conclusions:
- BC-EVD is associated with a significantly lower incidence and risk of complications than T-EVD.
- BC-EVD should be considered the primary choice for EVD placement.
- T-EVD retains a role for specific applications, such as in pediatric patients or intraoperative/occipital placements.
Background:
Acutely increased intracranial pressure (ICP) is frequently managed by external ventricular drainage (EVD). This procedure is life-saving but marred by a high incidence of complications. It has recently been indicated that bolt-connected external ventricular drainage (BC-EVD) compared to the standard technique of tunnelled EVD (T-EVD) may result in less complications.
Aim:
To prospectively sample and compare two cohorts by consecutive allocation to either BC-EVD or T-EVD from the introduction of the BC-EVD technique in our department and 12 months onward.
Methods:
Patients undergoing ventriculostomy between the 1st of March 2017 and the 28th of February 2018 were considered for inclusion. The neurosurgeon on-call sovereignly set the indication and decided on EVD type (BC-EVD or T-EVD), consequently resulting in two cohorts as 3/7 senior neurosurgeons on call were open to the use of BC-EVD, while 4/7 were reluctant to use this technique. Data was continuously collected using patient records, including results of cerebrospinal fluid (CSF) culturing and available CT/MRI-scans. Recorded complications included CSF leakage, accidental discontinuation, placement-related intracranial haemorrhage, malfunction, migration, infection and revision.
Results:
Forty-nine EVDs (32 T-EVDs/17 BC-EVDs) were included; 19/32 (59.4%) T-EVDs and 3/17 (17.6%) BC-EVDs were found to have complications (p = 0.007). The relative risk of complications when using T-EVD was 3.4 times that of BC-EVD.
Conclusion:
Ventriculostomy by BC-EVD compared to T-EVD reduces incidence and risk of complications and should be the first choice in EVD placement. That said, T-EVD has a role in paediatric patients and for intraoperatively and occipitally placed EVDs.
More Related Videos
07:14A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Guérin
Published on: October 9, 2016
08:01Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry
Published on: May 2, 2011
Related Concept Videos
Dietary Connections
Introduction to Connective Tissues
Classification of Connective Tissues
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
Embryonic Connective Tissues
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
Dense Connective Tissue
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Functions of Connective Tissues
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.