Related Experiment Video
Updated: Feb 2, 2026
12:55
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
22.1K
Adoptive cellular therapies: the current landscape.
Maartje W Rohaan1, Sofie Wilgenhof1, John B A G Haanen2
1Department of Medical Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Virchows Archiv : an International Journal of Pathology
|November 25, 2018
Summary
Adoptive cell therapy (ACT) harnesses the immune system to fight cancer, showing promise in various tumor types. This review covers ACT developments, toxicity, and future potential in cancer treatment.
Area of Science:
- Oncology
- Immunology
- Cancer Therapeutics
Background:
- The immune system is integral to cancer development and growth.
- Immunotherapeutic strategies have emerged based on novel insights into cancer immunology.
- Immune checkpoint blockade represents a significant advancement in cancer treatment.
Purpose of the Study:
- To review the advancements in Adoptive Cell Therapy (ACT) for cancer treatment.
- To discuss the associated toxicities of ACT.
- To explore the future potential of ACT in oncology.
Main Methods:
- Review of immune checkpoint blockade as a cancer treatment.
- Overview of Adoptive Cell Therapy (ACT) strategies, including tumor-infiltrating lymphocytes (TIL) and gene-modified T cells (TCR, CAR).
- Analysis of clinical trials and FDA-approved therapies, particularly CAR T cell therapy for hematological malignancies.
Main Results:
- Immune checkpoint blockade is approved for multiple tumor types.
- Adoptive Cell Therapy (ACT) using TIL, TCR, or CAR T cells shows promise in various cancers.
- CD19-directed CAR T cell therapy has achieved notable success and FDA approval for hematological malignancies.
Conclusions:
- ACT is a rapidly evolving field with significant potential in cancer treatment.
- Understanding and managing ACT-associated toxicity is crucial for optimizing patient outcomes.
- Continued research and clinical trials are essential to expand the application and efficacy of ACT in diverse cancer types.
Related Concept Videos
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
01:10Electrical Current
7.2K
Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
7.2K
01:26Group Therapy
443
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
443
01:21Current Density
5.1K
The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
5.1K
01:25Eddy Currents
2.6K
Since eddy currents occur only in conductors, magnets can separate metals from other materials. For example, in a recycling center, trash is dumped in batches down a ramp, beneath which lies a powerful magnet. Conductors in the trash are slowed by eddy currents, while nonmetals in the trash move on, separating from the metals. This works for all metals, not just ferromagnetic ones.
Other major applications of eddy currents appear in metal detectors and the braking systems of trains and roller...
Other major applications of eddy currents appear in metal detectors and the braking systems of trains and roller...
2.6K
01:19Displacement Current
3.8K
Ampère's law, in its usual form, does not work in places where the current changes with time and is not steady. Thus, Maxwell suggested including an additional contribution, called the displacement current, Id, to the real conduction current I.
3.8K