Functional neuroimaging of the central autonomic network: recent developments and clinical implications
Miriam Sklerov1, Eran Dayan2, Nina Browner3
1Department of Neurology, University of North Carolina, 170 Manning Drive, CB# 7025, Chapel Hill, NC, 27599, USA. sklerovm@neurology.unc.edu.
Summary
Functional neuroimaging, particularly fMRI, has significantly advanced our understanding of the central autonomic network (CAN). This technology offers promising potential as a biomarker for autonomic nervous system disorders.
Area of Science:
- Neuroscience
- Autonomic Nervous System Research
- Medical Imaging
Background:
- The central autonomic network (CAN) is a complex system crucial for autonomic nervous system regulation.
- In vivo studies of the human CAN were historically limited before functional neuroimaging techniques emerged.
Purpose of the Study:
- To review the impact of functional neuroimaging, specifically fMRI, on understanding the human CAN.
- To discuss recent advancements and future research directions in CAN imaging.
Main Methods:
- Literature review focusing on fMRI studies of the CAN in healthy and diseased states.
- Exclusion of studies on CAN function related to cognition, emotion, pain, and affective disorders to minimize confounding factors.
Main Results:
- fMRI has substantially improved the comprehension of human CAN function.
- The CAN comprises interconnected brainstem and forebrain structures vital for autonomic control.
Conclusions:
- fMRI has greatly enhanced knowledge of CAN function and shows potential as a disease biomarker.
- Continued advancements in fMRI present significant opportunities for future CAN research.
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