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Updated: Feb 2, 2026
10:56
Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
Published on: August 1, 2019
8.8K
The dual effect of morphine on tumor development
Summary
Morphine, a pain reliever, has conflicting effects on tumor development. This review comprehensively examines morphine
Area of Science:
- Oncology
- Pharmacology
- Pain Management
Background:
- Morphine is a primary opioid analgesic for cancer pain.
- Its peripheral actions cause side effects like nausea and addiction.
- Morphine's role in tumor development remains controversial.
Purpose of the Study:
- To comprehensively review morphine's effects on tumors.
- To summarize both promoting and inhibiting influences on tumor aspects.
- To explore impacts on growth, angiogenesis, metastasis, inflammation, and immunomodulation.
Main Methods:
- Extensive literature review.
- Synthesis of existing research findings.
- Analysis of studies on morphine and cancer.
Main Results:
- Conflicting evidence exists regarding morphine's impact on tumor growth.
- Morphine influences angiogenesis, metastasis, inflammation, and immune responses.
- Both pro-tumor and anti-tumor effects have been reported.
Conclusions:
- Morphine's dual role in cancer requires further investigation.
- Understanding these effects is crucial for optimizing pain management in cancer patients.
- Further research is needed to elucidate mechanisms and clinical implications.
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