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Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
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Recent Progress in Vascular Tissue-Engineered Blood Vessels.

Jun Chen1, Grant C Alexander1, Pratheek S Bobba1

  • 1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.

Advances in Experimental Medicine and Biology
|November 25, 2018
PubMed
Summary

Tissue-engineered blood vessels (TEBVs) offer promising alternatives to autologous veins for treating cardiovascular disease, the leading cause of death in the U.S. This review covers TEBV development, research, and clinical progress.

Keywords:
Animal modelsClinical studiesIn vitroScaffoldsTEBVTissue engineered blood vesselsTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Cardiovascular disease (CVD) is the leading cause of mortality in the U.S., incurring significant treatment costs.
  • Autologous veins are currently used for vascular replacement, but limitations exist.
  • Tissue-engineered blood vessels (TEBVs) are emerging as a viable alternative for CVD treatment.

Purpose of the Study:

  • To review current cell sources for TEBV fabrication.
  • To summarize methods employed in TEBV construction.
  • To present recent advancements in TEBV research and clinical applications.

Main Methods:

  • Review of scientific literature on TEBV cell sources and fabrication techniques.
  • Analysis of recent research findings in TEBV development.
  • Compilation of data from ongoing and completed TEBV clinical studies.

Main Results:

  • Diverse cell sources, including stem cells and endothelial cells, are utilized for TEBV engineering.
  • Various fabrication methods, such as scaffolds and bioreactors, are employed to create functional TEBVs.
  • Significant progress has been observed in preclinical research and early-phase clinical trials for TEBVs.

Conclusions:

  • TEBVs demonstrate potential as effective replacements for damaged or diseased blood vessels.
  • Continued research and clinical evaluation are crucial for the widespread adoption of TEBVs.
  • TEBV technology holds promise for improving outcomes in cardiovascular disease treatment.