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Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Overview of DNA Repair02:25

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Base Excision Repair01:54

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Updated: Feb 2, 2026

Visualization of MG53-mediated Cell Membrane Repair Using in vivo and in vitro Systems
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Regulatory T Cell-Mediated Tissue Repair.

Jihye Hong1, Byung-Soo Kim2,3,4

  • 1Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, South Korea.

Advances in Experimental Medicine and Biology
|November 25, 2018
PubMed
Summary

Regulatory T-cells (Treg cells) are crucial for immune balance. This review highlights their emerging role in tissue repair for conditions like heart attacks and muscle injuries, moving beyond autoimmune disease treatment.

Keywords:
InflammationRegulatory T cellTissue repair

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Regulatory T-cells (Treg cells) are vital for maintaining immune homeostasis by suppressing conventional T-cell responses.
  • Current Treg cell therapies primarily target autoimmune diseases due to their known role in preventing autoimmune defects.
  • Treg cells possess the unique ability to modulate inflammatory phases at injury sites.

Purpose of the Study:

  • To summarize the characteristics of regulatory T-cells (Treg cells).
  • To explore the therapeutic potential of Treg cells in tissue repair applications.
  • To review Treg cell applications in myocardial infarctions, skeletal muscle injuries, and ischemia injuries.

Main Methods:

  • Literature review of Treg cell characteristics and functions.
  • Analysis of existing studies on Treg cell-based therapies for tissue repair.
  • Discussion of limitations and future scope for Treg cell applications in regenerative medicine.

Main Results:

  • Treg cells can transition the inflammatory response to a regenerative phase at injury sites.
  • Successful Treg cell applications have been observed in treating myocardial infarctions, skeletal muscle injuries, and ischemia injuries.
  • Treg cells show promise as a novel therapeutic strategy for tissue repair.

Conclusions:

  • Regulatory T-cells (Treg cells) offer a promising avenue for tissue repair beyond their established role in autoimmune diseases.
  • Their ability to resolve inflammation and promote regeneration makes them valuable for treating various injuries.
  • Further research is needed to fully understand and optimize Treg cell-based regenerative therapies.