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Defining Treatment Effects: A Primer for Nonstatisticians
1Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Abstract:
It would often be of interest to know the effect of a drug compared to control in people who take the drug. However, different people will likely take the drug and the control. Thus, comparing takers of the drug to takers of the control does not yield a drug effect. Drug effects in drug takers can be estimated, but first they must be carefully defined.
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