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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Long non-coding RNAs and cervical cancer.

Hamid Aalijahan1, Saeid Ghorbian1

  • 1Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.

Experimental and Molecular Pathology
|November 25, 2018
PubMed
Summary

Long non-coding RNAs (lncRNAs) are key players in cervical cancer development and progression. This review highlights their roles and potential as biomarkers for early detection and targeted therapy.

Keywords:
BiomarkerCervical cancerHOTAIRLncRNAsPrognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cervical cancer is a leading cause of cancer death in women globally.
  • There is a critical need for novel biomarkers for early detection, prognosis, and metastasis prediction.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators in oncogenesis.

Purpose of the Study:

  • To review the roles of specific lncRNAs (HOTAIR, H19, XIST, etc.) in cervical cancer.
  • To discuss the potential of lncRNAs as biomarkers for cervical cancer diagnosis and prognosis.
  • To explore lncRNA involvement in tumor progression, metastasis, apoptosis, and radio-resistance.

Main Methods:

  • Comprehensive literature review of lncRNAs in cervical cancer.
  • Analysis of lncRNA functions in key oncogenic processes.
  • Discussion of lncRNA utility in clinical applications.

Main Results:

  • Several lncRNAs (e.g., HOTAIR, H19, MALAT1) are implicated in cervical cancer progression and metastasis.
  • lncRNAs influence tumor invasion, apoptosis, and resistance to radiotherapy.
  • Specific lncRNAs show promise as diagnostic and prognostic biomarkers.

Conclusions:

  • lncRNAs are crucial modulators in cervical cancer pathogenesis.
  • lncRNAs hold significant potential as biomarkers for diagnosis, prognosis, and targeted therapy.
  • Further research into lncRNAs can enhance survival outcomes for cervical cancer patients.