Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
03:29

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms

Published on: May 31, 2024

956

Quorum sensing inhibitors as antipathogens: biotechnological applications

Vipin Chandra Kalia1, Sanjay K S Patel1, Yun Chan Kang2

  • 1Department of Chemical Engineering, Konkuk University, Seoul 05029, Republic of Korea.

Biotechnology Advances
|November 25, 2018
PubMed

Insights

Quorum sensing (QS) allows microbes to cause infections and antibiotic resistance. Quorum sensing inhibitors (QSIs) show potential to combat these microbial threats in humans and agriculture.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pathogenesis

Background:

  • Microbial communication via signal molecules, termed quorum sensing (QS), is crucial for virulence.
  • QS regulates bacterial infectious diseases in eukaryotes, aiding pathogen evasion of host defenses.
  • QS contributes to antibiotic resistance through biofilm formation, efflux pump induction, and antibiotic production.

Purpose of the Study:

  • To review the role of quorum sensing inhibitors (QSIs) in combating microbial diseases.
  • To explore the application of QSIs in human, animal, and plant health.
  • To discuss challenges associated with the practical implementation of QSIs.

Main Methods:

  • Literature review of research on quorum sensing and QSIs.
  • Analysis of QS-mediated pathogenicity mechanisms.
  • Examination of diverse origins and applications of QSIs.

Main Results:

  • QSIs are identified as potential antipathogens.
  • QSIs offer a strategy to control QS-regulated virulence and antibiotic resistance.
  • Applications of QSIs span human, veterinary, and agricultural sectors.

Conclusions:

  • QSIs represent a promising therapeutic strategy against microbial infections.
  • Targeting QS offers an alternative to traditional antibiotics, potentially overcoming resistance.
  • Further research is needed to address challenges in the clinical and agricultural application of QSIs.
Keywords:
AntipathogensAquacultureBiofilmHuman healthInfectious diseasesInhibitorsPathogensQuorum sensing

More Related Videos

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing05:57

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

Published on: March 17, 2023

4.2K
Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

12.1K

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
605
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
21.8K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.5K
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
796