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In Vitro Transcription Assays and Their Application in Drug Discovery
Published on: September 20, 2016
Macrocycles: MCR synthesis and applications in drug discovery
Eman M M Abdelraheem1, Shabnam Shaabani2, Alexander Dömling2
1University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands; Chemistry Department, Faculty of Science, Sohag University, Sohag, 82524, Egypt.
Abstract:
Macrocycles are an emerging and largely underexploited part of chemical space where potential drugs for difficult genomic targets can be discovered. Macrocycles can have advantages over their natural twins such as better control over synthesis, physicochemical properties and target binding. Fast and convergent synthesis pathways are underdeveloped. Multicomponent reaction (MCR) chemistry is very well suited for the synthesis of a diverse range of macrocycles and is also able to generate great levels of molecular diversity and complexity at low synthetic costs.
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