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Arynes and isocyanides: Two close-knit partners in multicomponent reactions
Marta Serafini1, Tracey Pirali1
1Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Largo Donegani 2/3, 28100 Novara, Italy.
Drug Discovery Today. Technologies
|November 26, 2018
Summary
Benzyne chemistry has resurged due to mild in situ generation methods. This article highlights benzyne multicomponent reactions (MCRs) with isocyanides, particularly those using α-isocyanoacetamides.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Benzyne, known since 1940, has experienced renewed interest in recent decades.
- The resurgence is linked to the in situ generation of benzyne from stable, accessible precursors under mild conditions.
Observation:
- Arynes are highly reactive intermediates utilized in diverse chemical transformations.
- Multicomponent reactions (MCRs) involving arynes are particularly prominent.
Findings:
- This article focuses on MCRs that combine benzyne and isocyanides.
- It provides the first overview of aryne MCRs initiated by α-isocyanoacetamides.
Implications:
- These findings expand the synthetic utility of benzyne in complex molecule construction.
- The development of novel MCRs offers efficient pathways for creating diverse chemical structures.
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