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Updated: Feb 2, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
Published on: December 14, 2015
Understudied Skin Characteristics Awaiting Genetic Breakthroughs
1Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Abstract:
Skin is the human body's largest organ and the first to contact various environments. There are considerable variations of normal skin characteristics within and between populations. For example, skin containing more melanin looks darker, people with reduced axial sweating tend to have less body odor, and skin with higher lipid and water content has an improved barrier. For decades, dermatologists have been developing new methods to measure differences in normal skin characteristics. However, most of these studies were carried out at the clinical level. Research at the molecular level, in contrast, has become more common only in the last decade.
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