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Updated: Feb 2, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
Published on: May 14, 2021
A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis
1Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
The molecular pathomechanisms that drive keloid formation are only partially understood. Genetic studies have provided evidence for a genetic predisposition to keloid formation, and a keloid risk allele has been reported in the gene locus for the E3 ubiquitin ligase NEDD4. Fujita et al. (2018) explore the consequences of this genetic risk allele in NEDD4 for inflammation in the skin and for keloid pathogenesis. This study implicates a specific transcript variant of NEDD4, NEDD4-TV3, as a regulator of NF-κB/STAT3-mediated inflammation and provides evidence that an increase in NEDD4-TV3 promotes keloid formation.
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