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MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming.

Javier Prieto1, Arnold Y Seo2, Marian León1

  • 1Dpto. Biología Celular, Biología Funcional y Antropología Física, Universidad de Valencia, 46100 Burjassot, Spain.

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|November 26, 2018
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Summary
This summary is machine-generated.

Cell reprogramming involves a metabolic switch, but its control is unclear. We found c-MYC drives a hybrid metabolism early in reprogramming, enabling cells to gain plasticity for pluripotency.

Keywords:
cell reprogrammingcell signalingmetabolismmitochondrial dynamics

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Area of Science:

  • Cellular reprogramming and metabolism
  • Molecular biology
  • Biochemistry

Background:

  • Cell reprogramming is linked to a metabolic shift from oxidative to glycolytic metabolism.
  • The dynamics and control factors of this metabolic switch remain poorly understood.

Purpose of the Study:

  • To investigate the metabolic changes during cell reprogramming.
  • To identify the factors controlling the metabolic switch.
  • To understand how metabolic rewiring contributes to pluripotency.

Main Methods:

  • Cellular, biochemical, protein array, metabolomic, and respirometry analyses were employed.
  • Investigated the role of c-MYC in metabolic reprogramming.
  • Assessed mitochondrial membrane potential and metabolic profiles of cells undergoing reprogramming.

Main Results:

  • c-MYC establishes an early bivalent energetics program during cell reprogramming.
  • Cells capable of reprogramming show high mitochondrial membrane potential and a hybrid metabolic state.
  • This hybrid metabolism is characterized by both oxidative and glycolytic features.

Conclusions:

  • MYC proteins are key orchestrators of metabolic rewiring in early cell reprogramming.
  • Somatic cells gain metabolic plasticity necessary for transitioning to pluripotency.
  • This metabolic adaptation is crucial for responding to intrinsic or external cues driving pluripotency.