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The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation

Peter Ludewig1, Jack Winneberger1, Tim Magnus1

  • 1Department of Neurology at the University Medical Center Hamburg- Eppendorf, Hamburg, Germany.

Journal of Neuroimmunology
|November 26, 2018
PubMed

Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction. This review describes the current knowledge on the regulatory roles of endothelial cells in neuroinflammatory processes.

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