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Updated: Jul 23, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Fifteen-minute consultation: When medicines don't work-the child with poorly controlled seizures

Pooja Harijan1,2, Arnab Kumar Seal3, Manish Prasad4

  • 1Department of Paediatrics, Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, UK.

Archives of Disease in Childhood. Education and Practice Edition
|November 26, 2018
PubMed

Insights

Drug-resistant epilepsy (DRE) affects 20%-30% of pediatric epilepsy cases. Recent advancements in epilepsy surgery and multimodal evaluations have improved DRE management, with an algorithmic approach presented for affected children.

Area of Science:

  • Pediatric Neurology
  • Epileptology

Background:

  • Drug-resistant epilepsy (DRE) impacts 20%-30% of children with epilepsy.
  • DRE significantly affects pediatric patients' quality of life.

Purpose of the Study:

  • To review current evidence and expert opinion on managing DRE in children.
  • To present an algorithmic approach for diagnosing and managing pediatric DRE.

Main Methods:

  • Review of recent evidence and published opinions on DRE management in pediatric populations.
  • Development of a structured algorithmic approach for DRE evaluation.

Main Results:

  • Management strategies for pediatric DRE have advanced with streamlined epilepsy surgery services.
  • Quaternary multimodal evaluations are integral to current DRE management.

Conclusions:

  • Improved management protocols and surgical services offer better outcomes for children with DRE.
  • An algorithmic approach can guide clinicians in evaluating and treating pediatric DRE.

Keywords:
antiepileptic drugsdrug-resistant epilepsyepilepsy managementintractable epilepsyrefractory epilepsy

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