Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infectivity of secondary dapsone-resistant cases.

K Jesudasan1, V Pannikar, M Christian

  • 1Epidemiology and Leprosy Control Branch, Schieffelin Leprosy Research and Training Centre, Karigiri, Tamil Nadu, India.

International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of the factors contributing to endometriosis in China and UK].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2022
Same author

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.

Journal of internal medicine·2021
Same author

KRAS Status is Associated with Metabolic Parameters in Metastatic Colorectal Cancer According to Primary Tumour Location.

Pathology oncology research : POR·2020
Same author

Biomimetic graphene for enhanced interaction with the external membrane of astrocytes.

Journal of materials chemistry. B·2020
Same author

Quality of placental RNA: Effects of explant size and culture duration.

Placenta·2016
Same author

Architecture and inflammatory cell composition of the feline lung with special consideration of eosinophil counts.

Journal of comparative pathology·2014

Leprosy incidence among contacts of dapsone-resistant cases is similar to contacts of lepromatous leprosy. Primary dapsone resistance was detected in multibacillary leprosy cases, warranting further investigation into transmission dynamics.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Dapsone remains a cornerstone of leprosy treatment.
  • Secondary dapsone resistance poses a significant challenge to leprosy control.
  • Understanding transmission patterns of drug-resistant leprosy is crucial.

Purpose of the Study:

  • To determine the incidence of leprosy among household contacts of individuals with secondary dapsone resistance.
  • To assess the prevalence of primary dapsone resistance in contacts who developed leprosy.
  • To evaluate dapsone resistance in paucibacillary leprosy cases treated with monotherapy.

Main Methods:

  • Study involved 517 household contacts of 113 leprosy cases with secondary dapsone resistance.
  • Calculated leprosy incidence rate per 1000 person years at risk.

Related Experiment Videos

  • Assessed dapsone resistance in contacts who developed multibacillary and paucibacillary leprosy.

    • Main Results:

    • Leprosy incidence rate was 4.3 per 1000 person years at risk, comparable to contacts of lepromatous cases (4.8).
    • Two to three cases of primary dapsone resistance were identified among 27 contacts with multibacillary leprosy.
    • No dapsone resistance was found in 48 paucibacillary leprosy cases treated with dapsone monotherapy.

    Conclusions:

    • Secondary dapsone-resistant leprosy cases may pose a similar transmission risk as lepromatous leprosy.
    • Primary dapsone resistance can emerge in contacts, particularly in multibacillary forms.
    • Further research is needed to investigate the potential increase in primary dapsone resistance due to secondary resistant cases.