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Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
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MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population

W Liu, H Xiao, S Wu

    Acta Virologica
    |November 27, 2018
    PubMed

    Insights

    Single nucleotide polymorphisms (SNPs) in the MAP9 gene, specifically rs1058992, are linked to an increased risk of Epstein-Barr virus-associated gastric carcinoma (EBVaGC). This genetic variation may influence the development of EBVaGC.

    Area of Science:

    • Genetics
    • Oncology
    • Molecular Biology

    Background:

    • Microtubule-associated protein 9 (MAP9) plays a role in cell division and DNA damage response.
    • MAP9 dysregulation is implicated in tumorigenesis, and specific genetic variations in mitosis-related genes may increase gastric carcinoma susceptibility.

    Purpose of the Study:

    • To investigate the association between single nucleotide polymorphisms (SNPs) in the MAP9 gene and the risk of gastric carcinoma (GC), particularly EBV-associated GC (EBVaGC).

    Main Methods:

    • Genotyping analysis was performed to evaluate the association of MAP9 SNPs with EBVaGC.
    • Statistical analysis, including recessive genetic models and allele frequency calculations, was used to determine significance.

    Main Results:

    • The CC homozygous genotype of MAP9 SNP rs1058992 showed a significant correlation with EBVaGC (OR=2.558, P=0.043).
    • The C allele frequency of rs1058992 was also significantly associated with EBVaGC risk (OR=1.904, P=0.013).

    Conclusions:

    • The MAP9 rs1058992 polymorphism is associated with an increased risk of developing EBV-associated gastric carcinoma.
    • The rs1058992 polymorphism, potentially altering amino acids, may influence EBVaGC development, warranting further investigation in larger cohorts.

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