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Related Experiment Video

Updated: Feb 2, 2026

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

Modular microfluidics for double emulsion formation.

Bryant Thompson¹, Nareh Movsesian², Christine Cheng²

¹Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.

Methods in Cell Biology

|November 27, 2018

Summary

This summary is machine-generated.

Researchers developed a new method for creating microfluidic channels with controlled surface energies. This technique enables precise fabrication of channels for generating double emulsions, crucial for applications like single-cell analysis.

Keywords:

3D printed microfluidics Double emulsions Initiated chemical vapor deposition Modular microfluidics Surface energy iCVD

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Area of Science:

Materials Science
Chemical Engineering
Microfluidics

Background:

Controlling surface energy in microfluidic channels is vital for applications like two-phase flow manipulation and emulsion generation.
Fabricating microfluidic channels with alternating hydrophobic and hydrophilic properties for double emulsion formation presents a significant challenge.

Purpose of the Study:

To present a novel method for generating double emulsions using microfluidic channels with tailored surface properties.
To demonstrate a straightforward approach for creating controlled surface energy variations within microchannels.

Main Methods:

Utilized vapor-phase polymer coating technology-initiated chemical vapor deposition (CVD) to fabricate modular fluidic blocks.
Engineered blocks with distinct surface properties (hydrophobic/hydrophilic).
Assembled these modular blocks to create microchannels with step-like changes in surface energy.

Main Results:

Successfully fabricated microfluidic channels with precisely controlled, spatially varying surface energies.
Demonstrated the ability to generate double emulsions within these engineered microchannels.
The modular block assembly approach allows for adaptable and reproducible surface property patterning.

Conclusions:

The presented method offers a versatile and effective strategy for fabricating microfluidic devices with tunable surface properties.
This technique facilitates the controlled generation of double emulsions, advancing applications in areas such as single-cell analysis and lab-on-a-chip devices.