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TRPV1 neurons regulate β-cell function in a sex-dependent manner.

Joey Bou Karam1, Weikang Cai2, Rowaida Mohamed1

  • 1Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; The Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Molecular Metabolism
|November 27, 2018
PubMed
Summary

Transient receptor potential vanilloid type 1 (TRPV1) sensory neurons influence glucose control and insulin secretion. These effects are beneficial in males but not females, indicating sex-specific regulation.

Keywords:
Glucose homeostasisSex differenceTRPV1 sensory innervationβ-cell function

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Area of Science:

  • Neuroendocrinology
  • Metabolic Regulation
  • Sensory Physiology

Background:

  • Emerging evidence implicates transient receptor potential vanilloid type 1 (TRPV1) sensory innervation in glucose homeostasis.
  • The sex-specific and pancreatic β-cell-mediated roles of TRPV1 in glucose regulation remain unclear.

Purpose of the Study:

  • To investigate whether denervation of TRPV1 sensory neurons in male and female mice affects functional β-cell mass and systemic glucose homeostasis.
  • To determine if TRPV1 sensory neurons directly modulate pancreatic β-cell function.

Main Methods:

  • Utilized capsaicin-induced chemodenervation to ablate whole-body or pancreas-projecting TRPV1 sensory neurons.
  • Assessed islet β-cell function and mass, glucose and insulin homeostasis, and energy expenditure in male and female mice.

Main Results:

  • TRPV1 sensory denervation improved glucose clearance and enhanced glucose-stimulated insulin secretion in mice.
  • Denervation of intrapancreatic TRPV1 afferents lowered glucose levels and increased insulin release.
  • Beneficial effects on glucose tolerance and β-cell function were observed in males but not females.

Conclusions:

  • TRPV1 neurons partially regulate glucose homeostasis via direct modulation of glucose-induced insulin secretion.
  • This regulatory mechanism is sex-dependent, with effects observed only in male mice.