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Multifocal visual evoked potentials and contrast sensitivity correlate with ganglion cell-inner plexiform layer
Divya Narayanan1, Han Cheng1, Rosa A Tang2
1College of Optometry, University of Houston, Houston, TX, USA.
Summary
Optical coherence tomography (OCT) measures of macular ganglion cell-inner plexiform layer thickness (GCIPLT) and peripapillary retinal nerve fiber layer thickness (RNFLT) correlate with visual function in relapsing-remitting multiple sclerosis (RRMS). Multifocal visual evoked potential (mfVEP) and contrast sensitivity (CS) show strong relationships with OCT findings.
Area of Science:
- Ophthalmology and Neuroscience
- Neuro-immunology and Neuro-ophthalmology
Background:
- Relapsing-remitting multiple sclerosis (RRMS) can affect the optic nerve, leading to visual dysfunction.
- Assessing optic nerve integrity in RRMS is crucial for monitoring disease progression and treatment efficacy.
- Optical coherence tomography (OCT) and visual evoked potentials (VEPs) are key imaging and functional assessment tools.
Purpose of the Study:
- To investigate the correlation between OCT-derived macular ganglion cell-inner plexiform layer thickness (GCIPLT) and peripapillary retinal nerve fiber layer thickness (RNFLT).
- To examine the relationship of these OCT parameters with visual function, specifically multifocal visual evoked potential (mfVEP) and contrast sensitivity (CS), in patients with RRMS.
- To determine the utility of GCIPLT and RNFLT in assessing optic nerve damage in the context of RRMS, including eyes with and without a history of optic neuritis (ON).
Main Methods:
- A cross-sectional study involving 90 patients with RRMS, including eyes with a history of ON (>6 months prior) and eyes without ON.
- Measurements included Cirrus OCT for GCIPLT and RNFLT, VERIS 60-sector multifocal visual evoked potential (mfVEP) for amplitude and latency, and Pelli-Robson contrast sensitivity (CS).
- Statistical analyses were performed to correlate OCT parameters with mfVEP and CS measures.
Main Results:
- Both mfVEP measures and CS showed significant correlations with GCIPLT and RNFLT in both ON and non-ON eyes (r values ranging from -0.24 to 0.78, p < 0.03).
- In eyes with a history of ON, mfVEP amplitudes (central and global) correlated more strongly with GCIPLT (r=0.78, 0.76) than with RNFLT (r=0.43, 0.58; p < 0.01).
- mfVEP detected a significantly higher percentage of visual defects compared to OCT findings in eyes without a history of ON (45% vs. 22%, p < 0.0005).
Conclusions:
- GCIPLT, mfVEP, and CS are valuable measures for assessing optic nerve integrity in patients with RRMS.
- mfVEP amplitudes demonstrate a stronger association with GCIPLT than RNFLT in RRMS eyes with prior ON.
- mfVEP may be more sensitive than OCT in detecting visual pathway defects in non-ON eyes of RRMS patients.
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