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Report: A comparative study of loratidine physiochemical properties from different brands
1Faculty of Pharmacy, Jinn ah University for Women, Karachi, Pakistan.
Pakistan Journal of Pharmaceutical Sciences
|November 27, 2018
Summary
This study evaluated various loratadine brands for quality, finding all met British and United States Pharmacopoeia standards for physicochemical properties and dissolution. Loratadine quality control ensures effective allergy treatment.
Area of Science:
- Pharmaceutical Sciences
- Medicinal Chemistry
Background:
- Loratadine is a non-sedating antihistamine used for allergic conditions.
- It is a piperidine derivative with a long duration of action.
Purpose of the Study:
- To evaluate the quality control parameters of different loratadine brands.
- To assess compliance with British Pharmacopoeia (BP) and United States Pharmacopoeia (USP) specifications.
Main Methods:
- Physicochemical evaluations including weight variation, hardness, and friability.
- Disintegration time and dissolution studies using the paddle method (USP 2) in 0.1N HCl.
Main Results:
- All evaluated loratadine brands met BP/USP specifications for weight variation, hardness, and friability.
- Disintegration times were consistently below 15 minutes.
- All brands demonstrated over 80% drug release within 45 minutes.
Conclusions:
- The physicochemical properties and dissolution profiles of loratadine brands meet established quality standards.
- These findings confirm the quality and reliability of available loratadine products for allergy treatment.
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