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Cancer and mTOR inhibitors in kidney transplantation recipients

Chih-Chin Kao1,2,3, Jia-Sin Liu4, Yu-Kang Chang5

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Peerj
|November 27, 2018
PubMed
Abstract

Insights

mTOR inhibitors did not affect de novo cancer risk or mortality in kidney transplant recipients. Cumulative doses of these drugs also showed no association with increased cancer risk or death in Chinese patients.

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • mTOR inhibitors may reduce cancer risk post-kidney transplant.
  • The impact of cumulative mTOR inhibitor doses on cancer risk is unclear.

Purpose of the Study:

  • To investigate the association between mTOR inhibitor use and de novo cancer development after kidney transplantation.
  • To evaluate the effect of cumulative mTOR inhibitor doses on cancer risk and mortality.

Main Methods:

  • Retrospective analysis of 4,563 kidney transplant patients from a Taiwanese national database (2000-2013).
  • Patients were categorized into mTOR inhibitor users and non-users.
  • Follow-up until de novo cancer diagnosis, death, or end of 2014.

Main Results:

  • No significant difference in de novo cancer risk (HR 0.80) or mortality (HR 1.14) between mTOR inhibitor users and non-users.
  • Neither high nor low cumulative doses of mTOR inhibitors were linked to increased cancer or mortality risk.
  • Cancer subtypes and causes of mortality showed no significant differences between groups.

Conclusions:

  • mTOR inhibitor use was not associated with de novo cancer development or mortality in Chinese kidney transplant recipients.
  • Cumulative exposure to mTOR inhibitors did not alter these outcomes.
Keywords:
CancerChronic kidney diseaseKidney transplantationMortalitymTOR inhibitors

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