Related Experiment Video

Updated: Feb 2, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.9K

CMTCN: a web tool for investigating cancer-specific microRNA and transcription factor co-regulatory networks

Ruijiang Li1, Hebing Chen1, Shuai Jiang1

  • 1Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China.

Peerj
|November 27, 2018
PubMed

Insights

This study introduces CMTCN, a web tool for analyzing microRNA-transcription factor co-regulatory networks in cancer. It aids researchers in understanding gene regulation and its role in disease.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Transcription factors (TFs) and microRNAs (miRNAs) are key regulators of gene expression.
  • Dysregulation of TFs and miRNAs is linked to diseases, particularly cancer.
  • Understanding cooperative TF-miRNA regulatory networks is crucial for cancer research.

Purpose of the Study:

  • To develop a web tool for analyzing miRNA-TF co-regulatory networks.
  • To provide a resource for comprehensive analysis within specific cancer types.
  • To facilitate research into the role of these regulators in cancer.

Main Methods:

  • Development of the CMTCN web tool.
  • Construction of miRNA-TF co-regulatory networks.
  • Integration of topological and functional analyses.

Main Results:

  • CMTCN enables the construction and analysis of miRNA-TF co-regulatory networks.
  • The tool focuses on cancer-specific regulatory interactions.
  • User-friendly interface for topological and functional assessments.

Conclusions:

  • CMTCN is a valuable web resource for studying miRNA-TF co-regulation in cancer.
  • The tool supports biomedical research by providing insights into gene regulatory networks.
  • CMTCN is freely available for scientific use.
Keywords:
CancerCo-regulationMicroRNANetworkTranscription factorWeb tool

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.9K
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K

Related Concept Videos

Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.9K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.8K
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.1K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.8K