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Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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HIV-1 vaccine design through minimizing envelope metastability

Linling He1, Sonu Kumar2,3,4, Joel D Allen5

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science Advances
|November 27, 2018
PubMed
Summary

Minimizing HIV-1 envelope metastability using optimized gp41 ectodomain stabilizes trimers. This strategy enhances nanoparticle vaccine immunogenicity, inducing potent neutralizing antibody responses against HIV-1.

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