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Immunosuppression in the surgical patient
Journal of the National Medical Association
|May 1, 1988
Summary
This review examines the surgical patient's immune response, detailing immunosuppressive states like trauma and acquired immunodeficiency syndrome (AIDS). It explores immunopharmacology and immunomodulators for therapeutic goals.
Area of Science:
- Surgical immunology
- Immunopharmacology
Background:
- The surgical patient often experiences altered immune responses.
- Immunosuppressive states are common in surgical patients, including trauma, burns, sepsis, malnutrition, cancer, and acquired immunodeficiency syndrome (AIDS).
Purpose of the Study:
- To review the healthy and altered immune response in surgical patients.
- To discuss the development and implications of immunopharmacology.
Main Methods:
- Review of existing literature on immune responses in surgical patients.
- Description of endogenous and exogenous immunomodulators.
Main Results:
- Identification of various immunosuppressive states in surgical patients.
- Explanation of how immunopharmacology aims to modify host immune response.
- Overview of immunomodulators affecting the host immune response.
Conclusions:
- Understanding immune alterations is crucial for surgical patient care.
- Immunopharmacology offers therapeutic strategies by modulating the immune system.