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Updated: Feb 2, 2026

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
Oscillating dispersed-phase co-flow microfluidic droplet generation: jet length reduction effect.
Amin Shams Khorrami1, Pouya Rezai
1Department of Mechanical Engineering, York University, BRG 433B, 4700 Keele St, Toronto, ON M3J 1P3, Canada. prezai@yorku.ca.
A new method uses nozzle oscillation to control microdroplet generation, significantly reducing jet length and improving droplet size uniformity. This technique enhances droplet throughput and size control in microfluidic devices.
Area of Science:
- Microfluidics
- Fluid Dynamics
- Materials Science
Background:
- Co-flow droplet generation faces limitations in droplet polydispersity at high throughputs due to jetting instability.
- High dispersed-phase (d-phase) flow rates in co-flow systems lead to unstable jetting, hindering droplet size control.
Purpose of the Study:
- To introduce and evaluate a novel microdroplet generation technique using nozzle oscillation.
- To suppress the jetting effect and improve droplet size dispersity in microfluidic systems.
Main Methods:
- Oscillating the d-phase nozzle within the continuous phase (c-phase) channel.
- Systematically studying the effect of oscillation frequency (0-15 Hz) on jet length under varying d-phase and c-phase flow rates and d-phase viscosities.
Main Results:
- Oscillation significantly reduced jet length, with a maximum reduction of 70.8% observed at high d-phase and low c-phase flow rates.
- Jet length reduction was inversely proportional to oscillation frequency and directly proportional to d-phase flow rate.
- Nozzle oscillation led to the generation of smaller droplets compared to stationary methods and showed potential for simultaneous multi-size monodisperse droplet generation.
Conclusions:
- Nozzle oscillation is an effective active technique to suppress jetting instability in microdroplet generation.
- This method offers improved droplet size control and enhanced throughput, with potential applications in aqueous two-phase systems (ATPSs).
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