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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

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Neonatal gut colonization by Staphylococcus aureus strains with certain adhesins and superantigens is negatively

F L Nowrouzian1, A Ljung1, S Nilsson1

  • 1Institution for Biomedicine, Department of Infectious Disease, University of Gothenburg, Gothenburg, Sweden.

The British Journal of Dermatology
|November 27, 2018
PubMed

Insights

Early gut colonization by specific Staphylococcus aureus strains, particularly those with enterotoxin gene (egc) cluster and elastin-binding protein (ebp) genes, may protect infants from developing atopic eczema.

Area of Science:

  • Microbiology and Immunology
  • Dermatology
  • Pediatrics

Background:

  • Insufficient early immune stimulation is linked to atopic diseases.
  • Staphylococcus aureus, a common colonizer, produces immune-modulating substances like protein A and superantigens.
  • Previous research indicated a negative association between early gut colonization by specific S. aureus strains and atopic eczema development.

Purpose of the Study:

  • To replicate findings on S. aureus gut colonization and atopic eczema in a new birth cohort (FARMFLORA).
  • To investigate the relationship between nasal S. aureus colonization and subsequent atopic eczema.
  • To identify specific S. aureus virulence factors associated with protection against atopic eczema.

Main Methods:

  • Cultured S. aureus from fecal and nasal samples of infants in the FARMFLORA cohort (n=65) within the first two months of life.
  • Utilized random amplified polymorphic DNA for strain differentiation and PCR to detect adhesin and superantigen genes (including egc and ebp).
  • Correlated S. aureus colonization patterns and specific gene carriage with atopic eczema diagnosis at 18 months of age.

Main Results:

  • Overall S. aureus colonization did not predict eczema development.
  • Infants who developed atopic eczema had gut S. aureus strains less frequently carrying the elastin-binding protein (ebp) gene and enterotoxin gene (egc) cluster genes compared to healthy infants.
  • Nasal S. aureus colonization showed a less consistent association with subsequent eczema development.

Conclusions:

  • Findings replicate previous observations, suggesting a protective role for certain S. aureus strains.
  • Mucosal colonization by specific S. aureus strains may provide crucial immune stimulation.
  • This immune stimulation could strengthen the epithelial barrier, potentially preventing atopic eczema development.
Abstract

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