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Polymyxin Resistance Mechanisms: From Intrinsic Resistance to Mcr Genes

Georgios Meletis1, Lemonia Skoura1

  • 1Department of Microbiology, AHEPA University Hospital, S. Kiriakidi Str. 1, 54636, Thessaloniki, Greece.

Recent Patents on Anti-Infective Drug Discovery
|November 27, 2018
PubMed

Insights

Polymyxins are crucial for treating drug-resistant Gram-negative infections but rising resistance threatens their efficacy. This review details polymyxin resistance mechanisms and related patents.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Carbapenemase-encoding genes in Gram-negative pathogens necessitate polymyxin use.
  • Colistin and polymyxin B are last-resort antibiotics for multidrug-resistant infections.
  • Increasing polymyxin resistance and transferable genes limit treatment options.

Purpose of the Study:

  • To review current polymyxin resistance mechanisms.
  • To discuss patents associated with polymyxin resistance.

Main Methods:

  • Literature review of polymyxin resistance.
  • Analysis of patents related to polymyxin resistance.

Main Results:

  • Gram-negative pathogens exhibit diverse polymyxin resistance mechanisms.
  • Transferable resistance genes contribute significantly to polymyxin resistance.
  • Patents reflect ongoing research and development in combating polymyxin resistance.

Conclusions:

  • Polymyxin resistance is a growing threat to treating Gram-negative infections.
  • Understanding resistance mechanisms and patents is vital for future therapeutic strategies.
Keywords:
Polymyxincarbapenemase-encoding genescolistinmcr-1mgrBresistance.

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