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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
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A3 foresight network on natural products.

Linquan Bai1, Yasuo Ohnishi2,3, Eung-Soo Kim4

  • 1State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Journal of Industrial Microbiology & Biotechnology
|November 27, 2018
PubMed
Summary

Asian researchers from China, Japan, and Korea are collaborating on natural products (NPs) research. The A3 Foresight Network aims to create an Asian hub for NP discovery and synthetic biology, fostering international collaboration.

Keywords:
A3Genome miningNatural productStreptomycesSynthetic biology

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Area of Science:

  • Natural Products Chemistry
  • Synthetic Biology
  • Genomics

Background:

  • Natural products (NPs) are vital for human medicine and biotechnology.
  • Genome-mining techniques are increasingly used to discover novel NP biosynthetic gene clusters (BGCs).
  • Growing interest in NP research within Asian scientific communities, particularly China, Japan, and Korea.

Purpose of the Study:

  • To introduce the 'A3 Foresight Network on Chemical and Synthetic Biology of NPs' program.
  • To highlight key researchers involved in the A3 NP network.
  • To outline the future perspectives and goals of this collaborative Asian initiative.

Main Methods:

  • Genome-mining approaches for NP BGC discovery.
  • Establishment of a collaborative network involving researchers from China, Japan, and Korea.
  • Focus on chemical and synthetic biology of natural products.

Main Results:

  • Launch of the A3 Foresight Network, a government-sponsored program.
  • Formation of an Asian hub for natural product research and personnel exchange.
  • Increased focus on interdisciplinary NP research across three nations.

Conclusions:

  • The A3 NP network is poised to advance natural product discovery and development.
  • Enhanced collaboration is expected to accelerate innovation in chemical and synthetic biology of NPs.
  • The program will foster a new generation of Asian scientists in natural product research.