Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

7.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
7.3K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

3.8K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.8K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

4.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
4.9K
Total Voids in Concrete01:12

Total Voids in Concrete

485
Total voids in concrete encompass gel water volume, capillary pores, and entrapped air. Gel water (retained within the cement hydration products) and physically entrapped or adsorbed water are significant for the hydration process. For complete hydration, it's estimated that the space needed for the products of a cubic centimeter of cement doubles. Capillary pores constitute the unoccupied space within the hydrated cement paste, with their size largely influenced by the water-to-cement...
485
Brain Waves01:23

Brain Waves

4.1K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase-Dependent MoS<sub>2</sub> Nanosheets-Embedded Urinary Catheter for Advanced Photothermal Sterilization.

International journal of molecular sciences·2026
Same author

Early and Prolonged Cortical Electrical Stimulation Preserves Motor Functions and Nigrostriatal Dopaminergic Neurons in the MitoPark Model of Parkinson's Disease.

Journal of integrative neuroscience·2026
Same author

Effect of <i>Bifidobacterium longum</i> on cognition and microbiota in post-stroke patients: a single-blinded, controlled trial.

International journal of medical sciences·2026
Same author

Entheseal pain of levator ani muscle: A novel etiology in chronic pelvic pain and lower urinary tract symptoms-A urodynamic perspective.

Journal of the Chinese Medical Association : JCMA·2026
Same author

Transcranial direct current stimulation exerts neuroprotective effects in Parkinson's disease by restoring Mlst8-mediated autophagic homeostasis.

Journal of translational medicine·2026
Same author

Therapeutic Effects of Noninvasive Technology Modalities on Lower-Limb Motor Function in Spinal Cord Injury: A Systematic Review.

Archives of rehabilitation research and clinical translation·2026

Related Experiment Video

Updated: Feb 2, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K

Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions.

Chellappan Praveen Rajneesh1, Chien-Hung Lai2,3, Shih-Ching Chen2,3

  • 1School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan.

International Urology and Nephrology
|November 27, 2018
PubMed
Summary

Deep brain stimulation (DBS) effectively restored bladder function in rats after traumatic brain injury (TBI). This novel approach significantly improved voiding efficiency, offering a potential therapeutic avenue for TBI-related bladder dysfunction.

Keywords:
Cystometric analysisDeep brain stimulationsPnOTraumatic brain injuryWeight drop model

More Related Videos

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.6K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K

Related Experiment Videos

Last Updated: Feb 2, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.6K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K

Area of Science:

  • Neuroscience
  • Urology
  • Regenerative Medicine

Background:

  • Traumatic brain injury (TBI) is a significant global health issue with high mortality and disability rates.
  • Currently, no definitive therapy exists for TBI, and bladder dysfunction is a common and debilitating symptom.
  • Existing treatments for TBI-related bladder issues are limited in efficacy.

Purpose of the Study:

  • To investigate the therapeutic potential of deep brain stimulation (DBS) in alleviating bladder dysfunction following TBI in a rat model.
  • To evaluate the impact of specific DBS parameters on restoring normal voiding function.
  • To assess the effectiveness of DBS in mitigating the severity of TBI-induced bladder deficits.

Main Methods:

  • Traumatic brain injury (TBI) was induced using a standardized weight drop model (WDM) with optimized height (2m) to minimize mortality.
  • Bladder function was assessed using cystometric analysis in TBI-surviving rats.
  • Deep brain stimulation (DBS) was applied with varying parameters, and its effects were evaluated through cystometry and Magnetic Resonance Imaging (MRI).

Main Results:

  • The 2m WDM effectively induced TBI with minimal mortality, causing a significant reduction in voiding efficiency from 67% to 28%.
  • Deep brain stimulation (DBS) demonstrated a remarkable reversal of this deficit, restoring voiding efficiency to 65-84%.
  • MRI studies confirmed the extent of TBI-induced damage and precisely localized the DBS electrodes.

Conclusions:

  • Pons of Varol (PnO)-DBS exhibits a profound therapeutic effect on restoring voiding functions in rats subjected to TBI.
  • DBS offers a promising new strategy for managing bladder control impairments after traumatic brain injury.
  • This study highlights the potential of targeted neuromodulation for TBI rehabilitation.