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Related Concept Videos

Accelerators01:17

Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Average Acceleration01:30

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
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Acceleration Vectors01:30

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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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Accelerating Fluids01:17

Accelerating Fluids

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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
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Mouse Models of Accelerated Cellular Senescence.

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Cellular senescence, a key aging factor, can be detected in preclinical models. Targeting these senescent cells may extend lifespan and delay age-related diseases.

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Area of Science:

  • Gerontology
  • Cell Biology
  • Biomedical Research

Background:

  • Cellular senescence accumulates in vertebrate tissues with age.
  • Senescence is a conserved stress response that blocks damaged cell propagation.
  • Senescent cells contribute to aging and impede tissue regeneration.

Purpose of the Study:

  • To describe methods for detecting cellular senescence in vivo.
  • To focus on preclinical models, especially murine models of accelerated aging.
  • To address the challenge of identifying senescent cells due to lack of unique markers.

Main Methods:

  • Review and description of multiple detection methods for cellular senescence.
  • Emphasis on preclinical models, including those with accelerated aging.
  • Application of methods to assess the burden and location of senescent cells.

Main Results:

  • Established methods for detecting senescent cells in preclinical models.
  • Demonstrated the utility of these methods in accelerated aging models.
  • Highlighted the importance of measuring senescent cell burden and location.

Conclusions:

  • Detecting senescent cells is crucial for understanding aging.
  • Developed methods aid in studying senescence in preclinical aging models.
  • Further research into senescent cell targeting holds therapeutic potential.