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Bioinspired Concentric-Cylindrical Multilayered Scaffolds with Controllable Architectures: Facile Preparation and
Xiaopeng Cheng1, Honghui Shi1, Zhaofei Wang1
1College of Materials Science and Engineering, The First Affiliated Hospital of Zhengzhou University, Department of Immunology, National Engineering Research Center for Advanced Polymer Processing Technology , Zhengzhou University , Zhengzhou 450002 , P. R. China.
Abstract:
Multilayered objects are the most important and interesting structures in nature, exhibiting multiple functionalities. Inspired by the excellent structural-functional characteristics of nature creatures, concentric-cylindrical multilayered scaffolds were prepared by a combination of melt extrusion and leaching, in which well-defined alternating microlayer/gap is assembled. Furthermore, the macroscopic shape, internal structure, and surface topography of such a multilayered scaffold can be elaborately prepared by a simple physical process. The whole process has low cost, is efficient, and is environmentally friendly. Furthermore, such multilayered scaffolds show some interesting applications, e.g., lipophilic/hydrophilic drugs delivery and cell self-seeding. Considering the facile preparation process and versatile applications, this study will open up a new pathway to fabricate scaffolds with controllable architectures and expand their biodegradable polymer applications.
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