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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Iron Acquisition in Mycobacterium tuberculosis.

Alex Chao, Paul J Sieminski, Cedric P Owens1

  • 1Schmid College of Science and Technology , Chapman University , Orange , California 92866 , United States.

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Tuberculosis (TB) bacteria, Mycobacterium tuberculosis (Mtb), use complex iron and heme uptake strategies. Understanding these pathways offers new therapeutic targets for drug-resistant TB.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (Mtb).
  • Mtb exhibits alarming drug resistance, necessitating novel therapeutic strategies.
  • Iron acquisition is crucial for Mtb growth and virulence, making it a potential drug target.

Purpose of the Study:

  • To review the multifaceted strategies Mtb employs for iron and heme acquisition.
  • To identify potential therapeutic targets within Mtb's iron and heme uptake pathways.
  • To explore the possibility of utilizing these pathways for drug delivery into Mtb.

Main Methods:

  • Literature review of Mtb iron and heme acquisition mechanisms.
  • Analysis of Mtb's siderophore biosynthesis, export, and iron scavenging.
  • Examination of Mtb's heme uptake pathways and degradation mechanisms.

Main Results:

  • Mtb utilizes complex siderophore-mediated ferric iron uptake.
  • Mtb possesses dual heme uptake systems and a unique heme degradation pathway.
  • Iron and heme acquisition pathways are critical for Mtb virulence.

Conclusions:

  • Targeting Mtb's iron and heme acquisition machinery presents promising therapeutic avenues.
  • Novel anti-TB drugs can be developed by inhibiting these essential pathways.
  • Hijacking Mtb's iron/heme import systems may enhance drug penetration through the Mtb cell wall.